New

Research Scientist - Stem Cell Biology

Vertex Pharmaceuticals Incorporated
paid time off, 401(k)
United States, Massachusetts, Boston
50 Northern Avenue (Show on map)
Aug 22, 2025
Job Description Position Summary: Vertex seeks a Scientist to join the Vertex Cell and Genetic Therapies (VCGT) stem cell research group in Boston, MA. The group's mission is to discover and actualize the next generation of cell therapies for Type 1 diabetes. We are looking for a candidate with an interest in pluripotent stem cells and developmental biology with research experience in signal transduction pathways, functional proteomics, and cellular response pathways. The candidate with work closely with the Stem Cell Bio team on several discovery projects across diverse goals related to our cutting-edge stem cell derived therapeutics. The ideal candidate is scientifically independent and accustomed to taking initiative. The position requires strong communication and organization skills, as well as proven adaptability and multitasking capability. Key Responsibilities: Perform human pluripotent stem cell culture using both 2D and 3D culture systems Drive discovery research efforts in dissecting cell signaling and cell stress response pathways to optimize stem cell-islet cell differentiation. Lead teams use of analytical tools to evaluate molecular characteristics of stem cells and/or their differentiated stem cell-derived islets (SC-Islets) in a variety of culture systems Execute SOPs and contribute to stem cell differentiation campaigns (periodic weekend work is required) Work with cross-functional teams to plan, coordinate, and execute experiments Present findings to group and broader T1D teams, collaborate to summarize data into reports Scientific and Non-scientific Skills: Mammalian cell culture experience is required. Pluripotent stem cell culture experience (e.g., hESC and/or hiPSC) and 3D culture experience are helpful to be successful in this role Expertise in western blotting using Protein Simple instrumentation and other proteomic characterization techniques like ELISA assays, Luminex, and/or microarrays Standard molecular and cell biology techniques such as immunostaining, flow cytometry, RT-qPCR, and cell-based colorimetric or luminescence assays Must possess critical thinking and self-reliance to solve tasks independently Successful candidate will have outstanding organization and multitasking capability Proven track record of leading projects, both intellectually and at the bench Must possess flexibility to quickly pivot as projects demand Preferred Education and Experience Levels: Ph.D. (or equivalent degree) in molecular and cell biology, developmental biology, stem cell biology, or related disciplines and 0-3 years of relevant post-doctoral employment experience, or Masters Degree (or equivalent degree) in molecular and cell biology, developmental biology, stem cell biology, or related disciplines and 3+ years of relevant employment experience Pay Range: $104,200 - $156,300 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com