Postdoctoral Research Scientist

The Department of Pathology and Cell Biology at Columbia University Irving Medical Center seeks a highly qualified a postdoctoral fellow who will work on preclinical and translational studies as follows:

1. Unraveling effective strategies to delay metastatic progression by modulating the tumor microenvironment, specifically by targeting the tumor vasculature.
2. Investigating the role of vascular leakage in T-cell exclusion and tumor immune suppression.
3. Understanding the contribution of blood-brain barrier disruption to the progression of Alzheimer's disease.

At CUIMC, we stand together because diverse experiences, perspectives, and values enrich every dimension of our work. Join our team and see how your unique skills and experiences can create a real impact by changing lives.

Job Function:

• Data analysis
• Immunohistochemistry and imaging
• FACS and Single cell analysis
• Mouse treatment and perfusion
• Mouse maintenance

Lab Mission/Purpose:

Website: https://www.pathology.columbia.edu/research-labs/kim-lab

Selected Recent Publications:

-Lee E*, O'Keefe S*, Leong A*, Park HR, Varadarajan J, Chowdhury S, Kim S, Shiva A, Friedman R, Remotti H, Fojo A, Yang HW, Thurston G, and Kim M^#. Angiopoietin-2 promotes hepatic metastatic growth by restricting T-cell infiltration to the liver in pancreatic neuroendocrine tumors. J Clin Invest. In Press.

-Park HR*, Shiva A*, Cummings P, Kim S, Kim S, Lee E, Leong A, Chowdhury S, Shawber C, Carvajal R, Thurston G, An JY, Lund AW, Yang HW, Kim M^#. Angiopoietin-2-dependent spatial vascular destabilization promotes T-cell exclusion and limits immunotherapy in melanoma. Cancer Res. 2023 Jun 15;83(12):1968-1983. PubMed PMID: 37093870; PubMed Central PMCID: PMC10267677 (Cover article)

Minimum Education Requirements:

Requires a Ph.D. and/or M.D. in a related field

Minimum Skills Required:

• Molecular and animal work

• Analysis of immune cells

Preferred Qualifications:

The Kim Lab is looking for a postdoctoral fellow who will work on preclinical and translational studies based on various mouse tumor models and human specimens by using tools such as the following:

* Immune profiling using flow cytometry and multiplex staining.

* Single cell sequencing and spatial transcriptomics of mouse and human tissues.

* Imaging to determine vascular changes and function.

These experiences are preferred but not required.

Additional preferred qualifications of research area:

* Experience in cancer biology using mouse models and human tissues

* Experience in cancer immunology

* Experience in neurodegenerative diseases

Hiring Salary Range: $61,500-$61,500